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Published on: March 30, 2017
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[Blending powdered antineoplastic medicine in disposable ointment container]
Yasunori Miyazaki1, Tomonobu Uchino, Yoshiyuki Kagawa
1Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka.
Summary
A new method using a planetary centrifugal mixer in disposable containers ensures precise blending of powdered antineoplastic medicines, minimizing cross-contamination and environmental exposure for safer pharmacy practices.
Area of Science:
- Pharmaceutical Sciences
- Drug Formulation
- Pharmacy Practice
Background:
- Dispensing powdered antineoplastic medicines requires strict protocols to prevent cross-contamination and environmental exposure.
- Traditional methods like pestle and mortar can lead to apparatus contamination and increased environmental risk due to washing.
- A novel approach using a disposable container and planetary centrifugal mixer was developed to address these challenges.
Purpose of the Study:
- To evaluate the uniformity of medicine mixtures prepared using the new blending method.
- To quantify medicine weight loss during the blending procedure.
- To compare the new method with the traditional pestle and mortar technique.
Main Methods:
- Powdered medicines (Leukerin®, Mablin®) were blended with colored lactose using a planetary centrifugal mixer in disposable containers.
- Blending was assessed via image analysis, investigating variables like blending ratio, container size, and charging rate.
- Comparison was made against the standard pestle and mortar method.
Main Results:
- The new method achieved homogeneity with blending precision under 6.08% at a 20% charging rate in a 35 mL container, irrespective of blending ratio.
- Increased charging rates reduced blending precision.
- The disposable container method resulted in significantly less medicine weight loss compared to pestle and mortar.
Conclusions:
- A precise and safe method for blending powdered medicines in pharmacies has been established.
- The disposable container planetary centrifugal mixer method minimizes cross-contamination and environmental exposure.
- This technique offers improved safety for pharmacists handling potent powdered medications.
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