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Updated: Apr 30, 2026

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
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Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue

Published on: July 21, 2023

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Perivascular adipose tissue and coronary vascular disease

Meredith Kohr Owen1, Jillian N Noblet1, Daniel J Sassoon1

  • 1From the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill (M.K.O.); and Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis (J.N.N., D.J.S., A.M.C., A.G.G., J.D.T.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|May 3, 2014
PubMed

Insights

Coronary perivascular adipose tissue, once thought beneficial, may promote heart disease. This review explores how this fat tissue influences coronary vascular tone, inflammation, and atherosclerosis.

Area of Science:

  • Cardiovascular Science
  • Adipose Tissue Biology
  • Atherosclerosis Research

Background:

  • Coronary perivascular adipose tissue (CPAT) surrounds heart arteries.
  • CPAT was traditionally viewed as protective for vascular health.
  • Emerging evidence suggests CPAT has a unique phenotype and influences cardiovascular health.

Purpose of the Study:

  • To review existing findings on the cardiovascular effects of CPAT.
  • To explore potential mechanisms of CPAT-mediated influence on coronary vascular function.
  • To examine CPAT's role in atherogenesis.

Main Methods:

  • Literature review of studies on coronary perivascular adipose tissue.
  • Analysis of research on adipose-derived factors and cardiovascular effects.
  • Synthesis of evidence regarding CPAT's role in inflammation and vascular tone.

Main Results:

  • CPAT exhibits a distinct phenotype compared to other adipose depots.
  • Adipose-derived factors from CPAT can impact coronary vascular tone.
  • CPAT is implicated in promoting inflammation and coronary artery disease progression.

Conclusions:

  • CPAT plays a significant role in cardiovascular health beyond its structural function.
  • Understanding CPAT's mechanisms is crucial for addressing coronary artery disease.
  • Further research into CPAT's local factors may reveal therapeutic targets for atherosclerosis.

Keywords:
adipokinesadipose tissueobesity

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