Acute vitamin d toxicity in an infant

Area of Science:

• Pediatric Endocrinology
• Toxicology
• Nephrology

Background:

• Vitamin D is essential for bone health but can be toxic in large doses.
• Infantile hypercalcemia is a serious condition requiring prompt management.
• Nephrocalcinosis is a potential complication of hypercalcemia.

Purpose of the Study:

• To report a case of vitamin D toxicity in an infant.
• To describe the management of symptomatic hypercalcemia.
• To highlight the long-term sequelae of nephrocalcinosis.

Main Methods:

• Case report of an infant with vitamin D toxicity.
• Management of hypercalcemia using injectable calcitonin.
• Monitoring for complications such as nephrocalcinosis.

Main Results:

• Infant developed symptomatic hypercalcemia due to excessive vitamin D intake.
• Hypercalcemia was effectively managed with injectable calcitonin.
• Bilateral medullary nephrocalcinosis developed and persisted for 42 months.

Conclusions:

• Vitamin D toxicity can occur in infants from excessive supplementation.
• While hypercalcemia is treatable, nephrocalcinosis may be a persistent complication.
• Close monitoring is crucial following treatment for vitamin D toxicity in infants.