Jove
Visualize
Contact Us

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
1.4K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.1K
1.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

2.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K
Cancer Vaccines01:30

Cancer Vaccines

1.3K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
Cancer Therapies02:49

Cancer Therapies

2.4K
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interviews With Two Women's Health Experts On the Use of Estrogen Therapies.

P & T : a peer-reviewed journal for formulary management·2012
Same author

It's not easy being teen.

The American journal of nursing·2009
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 30, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

6.5K

Current and Emerging Treatment Regimens for HER2-Positive Breast Cancer.

Maribeth Maher

    P & T : a Peer-Reviewed Journal for Formulary Management
    |May 3, 2014
    PubMed
    Summary

    Overexpression of the human epidermal growth factor receptor 2 (HER2) drives cancer progression. Therapies targeting HER2-positive cancers are crucial for treating metastatic breast cancer.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Research

    Background:

    • Overexpression of human epidermal growth factor receptor 2 (HER2) is a significant factor influencing cancer survival, proliferation, and metastasis.
    • HER2-positive tumors represent a distinct subtype of cancer requiring specific therapeutic strategies.

    Purpose of the Study:

    • To review the role of HER2 in cancer progression.
    • To discuss the therapeutic strategies targeting HER2-positive tumors.

    Main Methods:

    • Literature review of studies on HER2 in cancer.
    • Analysis of clinical data on HER2-targeted therapies.

    Main Results:

    • HER2 overexpression is linked to poorer prognosis and increased metastatic potential.

    More Related Videos

    Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
    13:19

    Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

    Published on: April 26, 2024

    4.2K
    Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
    10:01

    Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

    Published on: August 2, 2022

    7.4K

    Related Experiment Videos

    Last Updated: Apr 30, 2026

    Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
    08:59

    Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

    Published on: December 11, 2017

    6.5K
    Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
    13:19

    Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

    Published on: April 26, 2024

    4.2K
    Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
    10:01

    Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

    Published on: August 2, 2022

    7.4K
  • Targeted agents show efficacy in HER2-positive metastatic breast cancer.
  • Conclusions:

    • Targeting HER2 is a validated approach in oncology.
    • Combination therapies and monotherapy with HER2 agents are vital for managing metastatic breast cancer.