Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

52
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
52
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

25
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
25
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

28
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
28

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Promoting Regeneration in Degenerative Disc Disease.

Maedica·2024
Same author

Superior rotational stability and lower re-ruptures rate after combined anterolateral and anterior cruciate ligament reconstruction compared to isolated anterior cruciate ligament reconstruction: a 2-year prospective randomized clinical trial.

The Physician and sportsmedicine·2022
Same author

Combined Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction Results in Superior Rotational Stability Compared with Isolated Anterior Cruciate Ligament Reconstruction in High Grade Pivoting Sport Patients: A Prospective Randomized Clinical Trial.

The journal of knee surgery·2021
Same author

Romanian medicine, European medicine.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2016
Same author

Venous thromboembolism following major orthopedic surgery.

Maedica·2013

Related Experiment Video

Updated: Apr 30, 2026

Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder
06:54

Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder

Published on: March 4, 2018

17.2K

Cerebral palsy gait, clinical importance.

Raluca Dana Tugui1, Dinu Antonescu2

  • 1"Prof. Agrippa Ionescu" Emergency Hospital, Bucharest, Romania.

Maedica
|May 3, 2014
PubMed
Summary

Cerebral palsy (CP) is a brain lesion causing permanent neurological disorders. Gait analysis aids in accurate motor diagnosis and treatment planning for CP patients.

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Physical Medicine and Rehabilitation

Background:

  • Cerebral palsy (CP) is a neurological disorder resulting from a lesion on an immature brain, leading to permanent motor deficits.
  • The incidence of CP remains constant at 2-2.5 per 1000 births, partly due to increased survival rates of premature infants.
  • Medical advancements have not changed CP treatment but highlight the need for precise diagnostic tools.

Purpose of the Study:

  • To elucidate the role of gait analysis in diagnosing and managing cerebral palsy.
  • To detail the components of gait analysis and their application in understanding CP-related motor deviations.

Main Methods:

  • Gait analysis encompasses four key areas: kinematics (body movements), kinetics (forces and moments), energy consumption (oximetry), and neuromuscular activity (electromyography/EMG).

More Related Videos

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

26.2K
Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models
08:24

Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models

Published on: August 11, 2023

2.9K

Related Experiment Videos

Last Updated: Apr 30, 2026

Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder
06:54

Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder

Published on: March 4, 2018

17.2K
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

26.2K
Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models
08:24

Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models

Published on: August 11, 2023

2.9K
  • Observing specific deviations in patient gait patterns through these analytical methods.

    • Main Results:

    • Gait analysis provides objective data on motor function in individuals with cerebral palsy.
    • Identification of specific gait deviations allows for tailored diagnostic conclusions.

    Conclusions:

    • Gait analysis is crucial for accurate motor diagnosis in cerebral palsy.
    • This analysis informs precise treatment strategies, including surgical interventions, botulinum toxin injections, orthotics, physical therapy, medications, and baclofen pumps.