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En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
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Aging aggravates nitrate-mediated ROS/RNS changes.

Qian Fan1, Lifen Chen2, Shujuan Cheng1

  • 1Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing 100029, China.

Oxidative Medicine and Cellular Longevity
|May 3, 2014
PubMed
Summary
This summary is machine-generated.

Nitrate therapy significantly increases oxidative stress in elderly patients more than adults. Aging and nitrates synergistically elevate reactive oxygen and nitrogen species, impacting endothelial function.

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Area of Science:

  • Cardiovascular Pharmacology
  • Gerontology
  • Biochemistry

Background:

  • Nitrates are widely prescribed, particularly for the elderly.
  • Both aging and nitrate use can increase in vivo reactive oxygen species (ROS) and reactive nitrogen species (RNS).
  • The impact of aging on nitrate-induced ROS/RNS alterations remains unclear.

Purpose of the Study:

  • To investigate the effects of aging on nitrate-induced alterations in ROS/RNS in vivo.
  • To compare nitrate therapy's impact on oxidative stress markers in adult versus elderly unstable angina patients.

Main Methods:

  • Clinical study involving adult (32) and elderly (43) unstable angina patients receiving intravenous isosorbide dinitrate.
  • Measurement of plasma malondialdehyde (MDA), myeloperoxidase (MPO), reduced glutathione (GSH), NOx, and nitrotyrosine at baseline and conclusion.
  • Confirmatory experiments in rats to assess cardiac tissue ROS/RNS stress and thoracic aortic nitric oxide synthase (NOS) activity.

Main Results:

  • Nitrate therapy significantly elevated in vivo ROS/RNS stress in elderly patients compared to adults.
  • Animal data confirmed increased ROS/RNS stress in aged rats.
  • Reduced NOS activity was observed in old rats, indicating impaired endothelial function.

Conclusions:

  • Nitrate treatment exacerbates in vivo oxidative and nitrogen species stress in the elderly.
  • A synergistic interaction exists between nitrate therapy and the aging process.
  • Aging may potentiate the adverse effects of nitrates on oxidative stress and endothelial function.