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Updated: Apr 30, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
NFkB and Nrf2 in esophageal epithelial barrier function
Hao Chen1, Yu Fang2, Wenbo Li3
1Cancer Research Program; JLC-BBRI; North Carolina Central University; Durham, NC USA.
Abstract:
The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we discuss the involvement of NFkB and Nrf2 in esophageal epithelial barrier function. Understanding these molecular pathways in the esophagus may help us develop therapeutic strategies to improve clinical outcomes in patients with GERD.
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