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Updated: Apr 30, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic
Muhammad Hanif1, Samuel M Meier2, Alexey A Nazarov3
1School of Chemical Science, The University of Auckland Auckland, New Zealand ; Institute of Inorganic Chemistry, University of Vienna Vienna, Austria ; Department of Chemistry, COMSATS Institute of Information Technology Abbottabad, Pakistan.
Abstract:
The synthesis and in vitro cytotoxicity of a series of Ru(II)(arene) complexes with carbohydrate-derived phosphite ligands and various arene co-ligands is described. The arene ligand has a strong influence on the in vitro anticancer activity of this series of compounds, which correlates fairly well with cellular accumulation. The most lipophilic compound bearing a biphenyl moiety and a cyclohexylidene-protected carbohydrate is the most cytotoxic with unprecedented IC50 values for the compound class in three human cancer cell lines. This compound shows reactivity to the DNA model nucleobase 9-ethylguanine, but does not alter the secondary structure of plasmid DNA, indicating that other biological targets are responsible for its cytotoxic effect.
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