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Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways

Kunio Doi1, Koji Uetsuka2

  • 1Bozo Research Center Inc., 8 Ohkubo, Tsukuba, Ibaraki 300-2611, Japan ; Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.

Journal of Toxicologic Pathology
|May 3, 2014
PubMed

Insights

Certain mycotoxins like T-2 toxin, citrinin, patulin, aflatoxin B1, and ochratoxin A can cause skin damage and tumors in rodents. Oxidative stress pathways are key to understanding these toxic effects.

Area of Science:

  • Toxicology
  • Dermatology
  • Molecular Biology

Background:

  • Mycotoxins are toxic secondary metabolites produced by fungi.
  • Several mycotoxins, including T-2 toxin, citrinin (CTN), patulin (PAT), aflatoxin B1 (AFB1), and ochratoxin A (OTA), are known to cause dermal toxicity and tumorigenesis in rodent models.
  • These toxins can induce apoptosis and possess tumor-initiating or promoting properties in skin.

Purpose of the Study:

  • To review the molecular mechanisms underlying the dermal toxicity and tumorigenesis induced by specific mycotoxins in rodent models.
  • To focus on the role of oxidative stress-mediated pathways in these toxicological effects.

Main Methods:

  • Literature review of studies investigating mycotoxin-induced dermal toxicity and tumorigenesis in rodents.
  • Analysis of research focusing on molecular mechanisms, particularly those involving oxidative stress.

Main Results:

  • T-2 toxin, CTN, PAT, and OTA induce apoptosis in mouse or rat skin.
  • PAT, AFB1, and OTA exhibit tumor-initiating properties.
  • OTA acts as a tumor promoter in mouse skin.
  • Oxidative stress-mediated pathways are implicated in the dermal toxicity and tumorigenesis.

Conclusions:

  • Mycotoxins pose a significant risk for dermal toxicity and skin cancer development.
  • Understanding the molecular mechanisms, especially oxidative stress pathways, is crucial for risk assessment and mitigation strategies.
Keywords:
T-2 toxinaflatoxin B1citrinindermal toxicitydermal tumorigenesisochratoxin Apatulin

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