Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

55
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
55
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

20
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
20
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

30
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
30
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

7.3K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Migraine and Stroke Risk in Postmenopausal Women in the Women's Health Initiative.

Neurology·2026
Same author

Mediation Analysis of Inflammatory Biomarkers in the Association between Migraine and Stroke among Postmenopausal Women: The Women's Health Initiative.

Neuroepidemiology·2026
Same author

Nonoperative management of patients with symptomatic carotid stenosis.

Seminars in vascular surgery·2026
Same author

CT Angiogram-Based Risk Stratification of Nonstenotic Carotid Plaques: An Important Step Forward.

Neurology·2026
Same author

Switching from Alteplase to Tenecteplase: Time to AcT?

Stroke (Hoboken, N.J.)·2026
Same author

Early prediction of Alzheimer's disease using longitudinal electronic health records of US military veterans.

Communications medicine·2026

Related Experiment Video

Updated: Apr 30, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

14.4K

Advances in stroke over the past decade.

Brian Silver1

  • 1Director, Stroke Center, Rhode Island Hospital; Associate Professor of Neurology, The Warren Alpert Medical School of Brown University.

Rhode Island Medical Journal (2013)
|May 3, 2014
PubMed
Summary

Recent advancements enhance stroke and TIA care, covering prevention, acute treatment, and recovery. This review highlights key updates in diagnosis, risk assessment, and therapeutic interventions for better patient outcomes.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Rehabilitation Science

Background:

  • Significant progress has been made in stroke and transient ischemic attack (TIA) patient care over the past decade.
  • These advancements span the continuum of care, including prevention, acute management, and recovery phases.
  • Notable contributions to this field have originated from research conducted in Rhode Island.

Purpose of the Study:

  • To review recent advancements in the care of stroke and TIA patients.
  • To focus on specific areas including revised definitions, risk assessment, and therapeutic interventions.
  • To provide an overview of the current state of stroke and TIA management and future directions.

Main Methods:

  • Literature review focusing on recent advancements in stroke and TIA care.
Keywords:
StrokeTIAacute interventionrecoveryrisk factors

More Related Videos

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

495
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

14.4K

Related Experiment Videos

Last Updated: Apr 30, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

14.4K
The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

495
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

14.4K

  • Synthesis of information on revised definitions, risk stratification, and management strategies.
  • Discussion of novel therapeutic approaches and interventions for stroke and TIA.

    • Main Results:

    • Revised definitions of stroke and TIA have been established.
    • Short-term risk stratification for TIA and rapid management protocols have been refined.
    • Advances include targeted medication, lifestyle modifications, and improved atrial fibrillation monitoring.
    • Novel anticoagulants and a better understanding of intra-arterial therapy limitations are discussed.
    • Clinical trials for intracerebral hemorrhage and innovative post-stroke functional recovery interventions are highlighted.

    Conclusions:

    • The comprehensive review underscores significant progress in stroke and TIA management.
    • Updated definitions, risk assessment, and therapeutic strategies aim to improve patient outcomes.
    • Emerging interventions in anticoagulation and post-stroke recovery offer promising avenues for future care.