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Urinary angiotensinogen level is increased in preterm neonates.
Masashi Suzue1, Maki Urushihara, Ryuji Nakagawa
1Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho 3-18-15, Tokushima, Tokushima, 770-8503, Japan.
Clinical and Experimental Nephrology
|May 6, 2014
Summary
Urinary angiotensinogen is higher in preterm infants, indicating potential intrarenal renin-angiotensin system activation during kidney development. Levels decrease with increasing gestational age in neonates.
Area of Science:
- Nephrology
- Developmental Biology
- Endocrinology
Background:
- The renin-angiotensin system (RAS) is crucial for kidney development.
- All RAS components are synthesized in the developing kidney.
Purpose of the Study:
- To measure urinary angiotensinogen in neonates.
- To examine the relationship between urinary angiotensinogen and gestational age.
Main Methods:
- Collected urine and plasma from 20 preterm and 18 full-term neonates.
- Measured angiotensinogen using enzyme-linked immunosorbent assay.
Main Results:
- Urinary angiotensinogen-to-creatinine ratio was higher in preterm neonates.
- Urinary angiotensinogen-to-creatinine ratio decreased with increasing gestational age.
- Plasma angiotensinogen did not differ between groups or correlate with gestational age.
Conclusions:
- Urinary angiotensinogen may reflect intrarenal RAS activation in prenatal kidney development.
- Gestational age influences urinary angiotensinogen levels in neonates.
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