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Updated: Apr 30, 2026

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Published on: February 21, 2018
IL-17F gene polymorphism is associated with susceptibility to acute myeloid leukemia
Tomasz Wróbel1, Katarzyna Gębura, Barbara Wysoczańska
1Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wrocław Medical University, Wybrzeże L. Pasteura 4, 50-367, Wrocław, Poland.
Purpose:
Recent studies have suggested that Th17 cells may play a role in the pathogenesis of acute myeloid leukemia (AML). This subset of CD4+ cells is characterized by interleukin (IL)-17A and IL-17F production, which share strong homology, and surface expression of the IL-23 receptor (IL-23R). The present study aimed to determine the association between the polymorphic features located within the IL-17A, IL-17F and IL-23R genes and disease susceptibility, progression and response to therapy. In addition, the relationship between the polymorphic variants and the plasma IL-17 levels in patients was analyzed.
Methods:
For this purpose, 187 individuals of Polish origin including 62 AML patients and 125 healthy controls were typed for IL-17A (rs2275913; G-197A), IL-17F (rs763780; A7488G; His161Arg) and IL-23R (rs11209026, G1142A; Arg381Gln) alleles.
Results:
The rs763780 IL-17F polymorphism appeared to be associated with susceptibility to the disease. The presence of the minor (G) variant (RR = 4.76, p < 0.001) and its homozygosity (RR = 23.02, p < 0.005) was more frequent among patients than healthy individuals. No significant association was observed for either other polymorphisms studied or IL-17 levels.
Conclusions:
Thus, the rs763780 IL-17F polymorphism was found to be associated with predisposition to AML in the Polish population.
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