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Updated: Apr 30, 2026

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Precision medicine clinical trials: defining new treatment strategies

Brandy M Heckman-Stoddard, Judith J Smith

    Seminars in Oncology Nursing
    |May 6, 2014
    PubMed
    Abstract

    Insights

    Clinical trials are evolving with new adaptive designs to personalize cancer care. These studies evaluate targeted therapies in specific patient groups, optimizing treatment delivery and identifying those most likely to benefit.

    Area of Science:

    • Oncology
    • Clinical Trial Design
    • Biomedical Technology

    Background:

    • Cancer care is shifting towards personalized treatment plans.
    • Biomarker discovery and technological advancements are key drivers of this change.
    • Traditional clinical trial models are being adapted to meet new challenges.

    Purpose of the Study:

    • To explore the role of clinical trials in personalized cancer care.
    • To discuss innovative randomized studies evaluating targeted therapies.
    • To highlight the integration of molecularly defined subsets in trial design.

    Main Methods:

    • Review of medical and nursing literature.
    • Analysis of research articles.
    • Inclusion of data from clinicaltrials.gov.

    Main Results:

    • Advancements in cancer biomarkers and technology are transforming cancer therapeutics.
    • Innovative adaptive trial designs are emerging.
    • Trials aim to determine not only safety and efficacy but also optimal delivery and patient benefit.

    Conclusions:

    • The cancer biomarker era necessitates specialized knowledge and skills for clinical trials.
    • Understanding molecular processes and ethical considerations is crucial.
    • Competent, safe, and effective healthcare requires expertise in biomarker-driven trials and patient communication.
    Keywords:
    Precision medicineadaptive designbiomarkerclinical trialmolecular targetsresearch ethics

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