Related Experiment Video
Updated: Apr 30, 2026
14:09
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
20.7K
Genetics of vasovagal syncope
Karl Martin Klein1, Samuel F Berkovic2
1Epilepsy Center Hessen, Department of Neurology, University Hospitals Giessen & Marburg, Philipps-University Marburg, Marburg, Germany.
Autonomic Neuroscience : Basic & Clinical
|May 6, 2014
Summary
Genetic factors significantly contribute to vasovagal syncope (VVS), a common condition affecting many. While most cases involve complex inheritance, some families show autosomal dominant patterns, indicating a genetic basis for VVS.
Area of Science:
- Genetics
- Cardiology
- Neurology
Background:
- Vasovagal syncope (VVS) is the most common cause of syncope, impacting approximately 25% of the population.
- The genetic underpinnings of VVS have been a subject of ongoing research and debate.
- This review synthesizes current evidence supporting a substantial genetic contribution to VVS.
Purpose of the Study:
- To review and discuss the evidence for a significant genetic component in vasovagal syncope.
- To explore the modes of inheritance observed in VVS families.
- To highlight the current state of molecular genetic studies in VVS.
Main Methods:
- Review of family aggregation and twin studies to assess genetic heritability.
- Analysis of family history data from affected individuals and their relatives.
- Examination of findings from candidate gene association studies and linkage analysis.
Main Results:
- Family aggregation and twin studies demonstrate higher concordance rates for VVS in monozygous twins compared to dizygous twins.
- Most VVS cases appear to follow complex inheritance patterns, but rare families exhibit autosomal dominant inheritance.
- A specific locus for VVS has been identified on chromosome 15q26 in an autosomal dominant family, though the causative gene remains unknown.
Conclusions:
- Genetic factors are confirmed to play a role in the etiology of vasovagal syncope.
- While complex inheritance is most common, autosomal dominant inheritance is observed less frequently.
- Identifying the specific genes involved in VVS is crucial for advancing our understanding of its pathophysiology and developing novel therapeutic strategies.
More Related Videos
09:36Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
2.0K
09:20Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
Published on: July 5, 2021
2.7K
Related Concept Videos
01:22Pathophysiology of Vomiting
4.5K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
4.5K
01:28Mechanism of Cardiac Arrhythmias
2.7K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.7K
01:27Principles of Pharmacogenetics: Types of Genetic Variants
138
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
138
01:28Human Genetics
2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
01:25Cardiomyopathy I: Introduction and Classification
826
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
826
01:19Electrophysiology of Normal Cardiac Rhythm
7.8K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
7.8K