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Updated: Apr 30, 2026

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MalarImDB: an open-access literature-based malaria immunology database.

Katrien Deroost1, Ghislain Opdenakker1, Philippe E Van den Steen1

  • 1Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven - University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.

Trends in Parasitology
|May 6, 2014
PubMed
Summary

The Malaria Immunology Database (MalarImDB) simplifies malaria research by organizing host mediator data. This tool aids scientists in comparing human and mouse studies to understand malaria

Keywords:
MalarImDBPlasmodiumblood-stage malariacerebral malariaclinical studiesmouse models

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Area of Science:

  • Immunology
  • Bioinformatics
  • Parasitology

Background:

  • Malaria research has generated extensive data on host mediators.
  • The complexity of this data presents challenges for researchers.
  • A centralized resource is needed to consolidate and analyze this information.

Purpose of the Study:

  • To introduce the Malaria Immunology Database (MalarImDB), a novel online tool.
  • To provide an open-access platform for exploring host mediators in blood-stage malaria.
  • To simplify literature searches and data comparison for malaria researchers.

Main Methods:

  • Developed a literature-based database (MalarImDB).
  • Integrated data on host mediators from published malaria studies.
  • Implemented multiple search engines for information retrieval.
  • Visualized search outputs in schematic tables for easy comparison.

Main Results:

  • MalarImDB allows comparisons of host mediator expression in humans and murine models.
  • Functional data from experimental treatments in mice is included.
  • The database facilitates the identification of similarities and disparities in host responses.
  • Provides a clear overview of available malaria host mediator data.

Conclusions:

  • MalarImDB offers a valuable resource for the malaria research community.
  • The database simplifies the process of navigating complex host mediator information.
  • Facilitates comparative analysis between human and animal models in malaria research.