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Related Experiment Video

Updated: Apr 30, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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DHEA and cognitive function in the elderly.

Marcello Maggio1, Francesca De Vita2, Alberto Fisichella2

  • 1Geriatric Rehabilitation Department, University Hospital of Parma, Via Gramsci, 14, 43126 Parma (PR), Italy; Department of Clinical and Experimental Medicine, Section of Geriatrics, Food Sciences Unit and Endocrinology of Aging Unit, University of Parma, Via Gramsci, 14, 43126 Parma (PR), Italy.

The Journal of Steroid Biochemistry and Molecular Biology
|May 6, 2014
PubMed
Summary
This summary is machine-generated.

Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) decline with age and are neurosteroids. While observational studies suggest a link between DHEA/S and cognitive function, clinical trials show inconsistent results for DHEA supplementation.

Keywords:
Cognitive functionDHEAOlder subjects

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Area of Science:

  • Neuroendocrinology
  • Neuroscience
  • Gerontology

Background:

  • Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are adrenal prohormones and neurosteroids that decrease with age.
  • DHEA/S has diverse biological activities, including potential neuroprotective effects, stimulating neurite growth, neurogenesis, and neuronal survival.

Purpose of the Study:

  • To review observational human studies and clinical trials investigating the relationship between DHEA/S levels and cognitive function in adults.
  • To assess the evidence for DHEA/S as a neurosteroid influencing cognitive performance and its potential therapeutic use.

Main Methods:

  • Literature search of PubMed (1994-2013) for observational studies on DHEA/S and cognition.
  • Analysis of cross-sectional and longitudinal studies, and randomized controlled trials (RCTs) examining cognitive outcomes with DHEA treatment.

Main Results:

  • Cross-sectional studies indicate a positive association between DHEA/S levels and cognitive function.
  • Longitudinal studies and RCTs using oral DHEA (50mg/day) in older adults yielded conflicting and inconsistent results regarding cognitive improvement.

Conclusions:

  • Current evidence does not clearly support the efficacy of DHEA treatment for enhancing cognitive function in older adults.
  • Further research is needed to clarify the role of DHEA/S in cognitive health and aging.