Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

130
Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These...
130
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

1.8K
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
1.8K
Antifungal Agents01:15

Antifungal Agents

119
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
119
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

2.3K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2.3K
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

1.0K
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
1.0K
Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

1.8K
Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Entropy-Regulated Dynamics of Surface Tension: Coupling Langmuir Kinetics with High-Precision Tensiometry.

The journal of physical chemistry. B·2026
Same author

Aqueous-phase DFT insights into ciprofloxacin adsorption on COOH-functionalized carbon nanotubes: energetics, electronic structure, and sesign principles.

Journal of molecular modeling·2025
Same author

Cyclodextrin-based inclusion complexes to enhance the solubility and oral bioavailability of indapamide: experimental and computational approaches.

Drug development and industrial pharmacy·2025
Same author

pH- and microhydration-corrected DFT insights into cucurbit[7]uril host-guest thermodynamics: toward predictive models for drug inclusion.

Journal of molecular modeling·2025
Same author

Elucidation of the Controlled-Release Behavior of Metoprolol Succinate from Directly Compressed Xanthan Gum/Chitosan Polymers: Computational and Experimental Studies.

ACS biomaterials science & engineering·2021
Same author

Influence of Chitin Source and Polymorphism on Powder Compression and Compaction: Application in Drug Delivery.

Molecules (Basel, Switzerland)·2020

Related Experiment Video

Updated: Apr 30, 2026

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
12:29

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

4.6K

Moxifloxacin hydrochloride.

Mahmoud M H Al Omari1, Deema S Jaafari1, Khaldoun A Al-Sou'od2

  • 1The Jordanian Pharmaceutical Manufacturing Co., PO Box 94, Naor, Jordan.

Profiles of Drug Substances, Excipients, and Related Methodology
|May 6, 2014
PubMed
Summary

This comprehensive profile details moxifloxacin HCl, covering its preparation, properties, and applications. It serves as a valuable resource for understanding this important fluoroquinolone antibiotic.

Keywords:
ADMEAnalysisAntibacterial agentComprehensive profileFluoroquinoloneMoxifloxacinPreparationStability

More Related Videos

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
09:24

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

7.5K
High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
07:25

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence

Published on: February 23, 2021

3.4K

Related Experiment Videos

Last Updated: Apr 30, 2026

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
12:29

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

4.6K
Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
09:24

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

7.5K
High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
07:25

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence

Published on: February 23, 2021

3.4K

Area of Science:

  • Pharmaceutical Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Moxifloxacin HCl is a widely used fluoroquinolone antibiotic.
  • Comprehensive profiles are essential for understanding drug properties and applications.

Purpose of the Study:

  • To provide a detailed profile of moxifloxacin HCl.
  • To consolidate information on its preparation, properties, and uses.

Main Methods:

  • Literature review and synthesis of existing data.
  • Compilation of information on nomenclature, formulae, and elemental analysis.
  • Description of preparation methods for moxifloxacin HCl, intermediates, and derivatives.

Main Results:

  • A full description of moxifloxacin HCl, including its physical and chemical properties.
  • Detailed discussion of analytical methods, stability, and pharmacological aspects.
  • Inclusion of 198 references for comprehensive data support.

Conclusions:

  • This profile offers a thorough overview of moxifloxacin HCl.
  • It serves as a key reference for researchers and professionals in the field.
  • The compilation aids in the understanding and application of moxifloxacin HCl.