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Synthesis of Plant Phenol-derived Polymeric Dyes for Direct or Mordant-based Hair Dyeing
Published on: December 1, 2016
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In defence of 'dye therapy'
1School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK.
International Journal of Antimicrobial Agents
|May 6, 2014
Summary
Photoantimicrobial chemotherapy offers a promising, resistance-free solution to rising drug-resistant infections. This approach, using safe cationic dyes, can be locally administered to preserve conventional antibiotics.
Area of Science:
- Antimicrobial chemotherapy
- Photodynamic therapy
- Infectious disease treatment
Background:
- Global rise in drug-resistant infectious diseases poses a significant healthcare challenge.
- Scarcity of novel antimicrobial agents and pharmaceutical industry withdrawal necessitate alternative therapeutic strategies.
- Existing photoantimicrobial chemotherapy is effective and does not induce resistance but faces limited adoption.
Purpose of the Study:
- To highlight the potential of photoantimicrobial chemotherapy as an alternative to conventional antibiotics.
- To advocate for the reintroduction of safe, cationic biological dyes as light-activated antimicrobial agents.
- To propose the local administration of these agents to conserve valuable conventional antibacterial drugs.
Main Methods:
- Review of historical antiseptic 'dye therapy' and its evolution.
- Examination of cationic biological dyes (e.g., methylene blue, crystal violet, acriflavine) for antimicrobial properties.
- Proposal for the application of these dyes in light-activated antimicrobial therapeutics.
Main Results:
- Cationic biological dyes demonstrated efficacy in historical local wound therapy.
- These dyes provide a foundation for developing effective light-activated antimicrobial therapeutics.
- Photoantimicrobial chemotherapy is highly effective against a broad range of microbial pathogens without resistance development.
Conclusions:
- Photoantimicrobial chemotherapy, rooted in historical dye therapy, offers a viable solution to antimicrobial resistance.
- Safe cationic dyes like methylene blue, crystal violet, and acriflavine can be repurposed as local photoantimicrobials.
- Local administration of these agents can help conserve critical conventional antibacterial drugs.
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