Related Experiment Video
Updated: Apr 30, 2026

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
Published on: January 27, 2023
Abstract:
Hepatic encephalopathy is frequently accompanied by reversible cognitive impairment, while chronic acquired hepatocerebral degeneration is a rare irreversible neurological disorder in patients with liver cirrhosis, characterized by parkinsonism and cognitive decline. Patients with Wilson disease can also present cognitive deficits. Recently, it was reported that non-alcoholic fatty liver disease (NAFLD) might be a risk factor for cognitive impairment. There may be the links among obesity, type 2 diabetes mellitus, NAFLD, insulin resistance and cognitive impairment. Reduced liver biosynthesis of docosahexaenoic acid (DHA) might also contribute to cognitive decline in Alzheimer's disease. The associations between chronic liver diseases and cognitive impairment need further investigation.
Related Concept Videos
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis I: Introduction
Cirrhosis II: Pathophysiology
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Liver Physiology
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Liver Histology
Hepatocytes perform a variety of essential functions. They secrete...

