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The Oral Microbiota

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

Tooth Anatomy

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
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Oral Cavity

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The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

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Related Experiment Video

Updated: Apr 30, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

[Periodontal disease].

Makoto Michikawa

Nihon Rinsho. Japanese Journal of Clinical Medicine

|May 7, 2014

Summary

Inflammation in periodontal disease may impact Alzheimer disease (AD) development and progression. Research reviews the link between periodontitis and AD, exploring mechanisms of influence.

Area of Science:

Neuroscience
Immunology
Periodontology

Context:

Alzheimer disease (AD) involves brain inflammation.
Anti-inflammatory drugs show potential in reducing AD risk.
Periodontal disease is a significant source of systemic inflammation.

Purpose:

To review the relationship between periodontitis and Alzheimer disease.
To discuss potential mechanisms linking periodontal disease to AD onset and progression.

Summary:

Inflammatory pathways are activated in Alzheimer disease (AD) brains.
Molecules involved in inflammation can promote AD pathology or protect neurons.
Emerging evidence links periodontal disease, a cause of inflammation, to AD.

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Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

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In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

Related Experiment Videos

Last Updated: Apr 30, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

Impact:

Understanding the link between periodontal disease and AD can inform preventative strategies.
This review highlights potential therapeutic targets for mitigating AD progression through managing oral health.
Further research into the shared inflammatory mechanisms could lead to novel treatments for both conditions.