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Updated: Apr 30, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Impact of mono- and disubstitution on the colorimetric dynamic covalent switching chalcone/flavanone scaffold
Brian M Muller1, Jesse Mai, Reid A Yocum
1Department of Chemistry & Biochemistry, Northern Illinois University, 1425 W Lincoln Hwy, DeKalb, IL 60115, USA. mjadler@niu.edu.
Abstract:
The effect of aryl substitution on various aspects of the interconversion of ortho-hydroxychalcones and flavanones has been studied using multiple spectroscopic techniques. Derivatization of the core scaffold predictably alters the midpoint pH of this equilibration process suggesting its viability for application as a functional colorimetric molecular switch.
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