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Updated: Apr 30, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis

Jodie N Painter¹, Dale R Nyholt¹, Lutz Krause¹

¹QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Fertility and Sterility

|May 7, 2014

Abstract

Objective:

To follow-up previous studies highlighting a possible role for cytochrome P450, family 2, subfamily C, 19 (CYP2C19) in susceptibility to endometriosis by searching for additional variants in the CYP2C19 gene that may be associated with the disease.

Design:

Case-control study.

Setting:

Academic research.

Subject(S):

The cases comprised 2,271 women with surgically confirmed endometriosis; the controls comprised 939 women with self-report of no endometriosis and 1,770 unscreened population samples.

Intervention(S):

Sequencing of the CYP2C19 region and follow-up of 80 single nucleotide polymorphisms (SNPs) in two case-control samples.

Main Outcome Measure(S):

Allele frequency differences between cases and controls.

Result(S):

Sequencing of the CYP2C19 gene region resulted in the detection of a large number of known and novel SNPs. Genotyping of 80 polymorphic SNPs in 901 endometriosis cases and 939 controls resulted in study-wide significant association signals for SNPs in moderate or complete linkage disequilibrium with rs4244285, a functional SNP in exon 5 that abrogates CYP2C19 function through the creation of an alternative splice site. Evidence of association was also detected for another functional SNP in the CYP2C19 promoter, rs12248560, which was highlighted in our previous study.

Conclusion(S):

Functional variants in CYP2C19 may contribute to endometriosis susceptibility in both familial and sporadic cases.

Keywords:

CYP2C19 Endometriosis association pooled sequencing rs12248560 rs4244285

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