Related Experiment Video
Updated: Apr 30, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
The silicon trypanosome: a test case of iterative model extension in systems biology
Fiona Achcar1, Abeer Fadda2, Jurgen R Haanstra3
1Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Abstract:
The African trypanosome, Trypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology.
Related Concept Videos
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model
Model Approaches for Pharmacokinetic Data: Physiological Models
Two-Compartment Open Model: Overview
The...
Evolutionary Processes in Microbes

