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Hyperhomocysteinemia, lipid and lipoprotein disturbances in patients with primary hypertension

Aleksandra Baszczuk1, Katarzyna Musialik2, Jarosław Kopczyński2

  • 1Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.

Advances in Medical Sciences
|May 7, 2014
PubMed

Insights

Patients with primary hypertension and hyperhomocysteinemia exhibit lower HDL-cholesterol and apo A-I levels. Elevated homocysteine correlates negatively with these lipid and lipoprotein parameters, suggesting increased atherosclerosis risk.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Lipid Metabolism

Background:

  • Primary hypertension is a significant risk factor for cardiovascular disease.
  • Hyperhomocysteinemia, elevated homocysteine levels, is also linked to increased cardiovascular risk.
  • The interplay between hypertension, hyperhomocysteinemia, and lipid profiles requires further elucidation.

Purpose of the Study:

  • To determine serum concentrations of lipids and lipoproteins in patients with primary hypertension and hyperhomocysteinemia.
  • To investigate correlations between homocysteine levels and lipid/lipoprotein parameters in hypertensive patients.

Main Methods:

  • Study included 42 patients with primary hypertension and hyperhomocysteinemia, and 20 healthy controls.
  • Homocysteine measured by Fluorescence Polarization Immunoassay (FPIA).
  • Lipids (total cholesterol, LDL-C, HDL-C, triglycerides) measured enzymatically.
  • Apolipoproteins (apo A-I, apo B) and lipoprotein(a) measured nephelometrically.

Main Results:

  • Patients with primary hypertension and hyperhomocysteinemia showed significantly lower HDL-cholesterol and apo A-I concentrations compared to hypertensive individuals with normal homocysteine.
  • A negative correlation was observed between homocysteine levels and HDL-cholesterol.
  • A negative correlation was also found between homocysteine and apo A-I.

Conclusions:

  • The findings suggest that individuals with primary hypertension and hyperhomocysteinemia may have a higher susceptibility to atherosclerosis.
  • Lower HDL-cholesterol and apo A-I in this population underscore the combined atherogenic risk.
  • Further research is warranted to explore therapeutic strategies targeting homocysteine and lipid profiles in hypertensive patients.
Abstract

Keywords:
ApolipoproteinCholesterolHyperhomocysteinemiaHypertensionTriglycerides

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