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Augmentation of rat liver regeneration by FK 506 compared with cyclosporin

A Francavilla1, M Barone, S Todo

  • 1Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pennsylvania.

Lancet (London, England)
|November 25, 1989
PubMed

Abstract:

The immunosuppressive drug, FK 506, increased the regeneration response that follows 40% and 70% hepatectomy in rats. The effect was similar to that obtained with cyclosporin.

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Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

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