Related Experiment Video
Updated: Apr 30, 2026

08:23
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
11.2K
Priapism in a patient with sickle cell trait using marijuana
Abhishek Matta1, Pavan Kumar Tandra, Lyudmyla Berim
1Department of Internal Medicine, Creighton University Medical Center, Omaha, Nebraska, USA.
BMJ Case Reports
|May 7, 2014
Summary
Priapism, a prolonged erection, can be a medical emergency. This case highlights successful surgical intervention for refractory priapism in a patient with sickle cell trait.
Area of Science:
- Urology
- Hematology
Background:
- Priapism is a prolonged erection, often requiring urgent medical attention.
- Sickle cell trait can be associated with priapism, though not always with a known family history.
Observation:
- A 22-year-old male presented with a 48-hour erection refractory to home management.
- He had a positive sickle solubility test and confirmed sickle cell trait, with a positive urine drug screen for cannabinoids.
Findings:
- Initial treatment with intracavernosal phenylephrine was unsuccessful.
- A limited El-Ghorab procedure provided partial relief.
- A subsequent bilateral El-Ghorab procedure successfully resolved the priapism.
Implications:
- This case underscores the importance of considering sickle cell trait in priapism evaluation.
- Surgical intervention, such as the El-Ghorab procedure, may be necessary for refractory cases.
- Prompt and effective management is crucial to prevent long-term complications of priapism.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
1.1K
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
1.1K
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
823
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
823

