Related Experiment Video
Updated: Apr 30, 2026
08:32
Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
Published on: February 22, 2019
6.7K
Splenic marginal-zone lymphoma: ontogeny and genetics
Panagiotis Baliakas1, Jonathan C Strefford, Vasilis Bikos
1Department of Immunology, Genetics and Pathology, Science for Life laboratory, Uppsala University , Uppsala , Sweden.
Leukemia & Lymphoma
|May 7, 2014
Summary
Splenic marginal-zone lymphoma (SMZL) research reveals molecular subgroups and genomic aberrations. Understanding these factors is key to classifying SMZL and improving diagnosis and treatment strategies.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Splenic marginal-zone lymphoma (SMZL) is a rare B-cell lymphoma.
- Recent studies highlight the interplay of genetics and environment in lymphoma development.
- SMZL serves as a model for understanding these complex interactions.
Purpose of the Study:
- To review recent advances in the molecular and cellular biology of SMZL.
- To emphasize the role of immunogenetics and genomic aberrations in SMZL.
- To discuss the utility of molecular and cellular markers for diagnosis.
Main Methods:
- Review of recent high-throughput studies on SMZL.
- Analysis of genomic aberrations and molecular immunogenetic subgroups.
- Synthesis of current knowledge on SMZL biology.
Main Results:
- SMZL lacks a single characteristic genetic lesion but frequently harbors genomic aberrations.
- Recurrent genetic aberrations identified in pathways of marginal-zone differentiation and B-cell signaling.
- Molecular subgroups within SMZL are emerging, potentially impacting classification and biology.
Conclusions:
- Molecular and immunogenetic insights are crucial for understanding SMZL.
- Genomic aberrations play a significant role in SMZL pathogenesis.
- Molecular and cellular markers hold promise for improved diagnosis and differential diagnosis of SMZL.
Related Concept Videos
01:21Hematopoiesis
8.1K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.1K
01:16Primary Lymphoid Organs
9.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
9.6K
01:18Lymphoid Cells and Tissues
3.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.4K
01:21Lineage Commitment
3.4K
Commitment is the process whereby stem cells:
3.4K
01:15Secondary Lymphoid Organs
7.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
7.2K
01:01Regulation of Hematopoietic Stem Cells
3.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.4K