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Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene?

Jennifer A Byrne1, Sarah Frost, Yuyan Chen

  • 1Molecular Oncology Laboratory, Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, 2145, NSW, Australia, jennifer.byrne@health.nsw.gov.au.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|May 7, 2014
PubMed

Insights

Tumor protein D52 (TPD52) is overexpressed in many cancers due to gene amplification. This review details TPD52

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The Tumor protein D52 (TPD52) gene was identified due to its overexpression in human cancers.
  • TPD52 is a gene amplification target at chromosome 8q21.13, frequently overexpressed in various tumors.

Purpose of the Study:

  • To review the significance of TPD52 overexpression and its targeting in cancer.
  • To update on TPD52's role in tumors with known and newly reported overexpression/amplification.
  • To explore TPD52's potential as a cancer biomarker and immunotherapeutic target.

Main Methods:

  • Literature review of studies on TPD52 gene expression, amplification, and function in cancer.
  • Analysis of recent findings on microRNA regulation of TPD52.
  • Investigation into TPD52's cellular functions, particularly in cancer cells.

Main Results:

  • TPD52 overexpression/amplification is confirmed in several tumor types and variably reported in others.
  • MicroRNA regulation of TPD52 expression has been demonstrated in experimental systems.
  • Progress has been made in understanding TPD52's cellular functions relevant to cancer.

Conclusions:

  • TPD52 is a significant factor in multiple cancer types, warranting further investigation.
  • TPD52 holds potential as a diagnostic biomarker and a target for cancer immunotherapy.
  • Despite its prevalence, TPD52 remains relatively understudied, highlighting its therapeutic promise.

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