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Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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Psoriasis beyond the skin surface: a pilot study on the ocular involvement.

A Campanati¹, P Neri, K Giuliodori

¹Dermatology Unit, University of Marche, Azienda Ospedaliera Universitaria-Ospedali Riuniti di, Ancona Via Conca 71, 60126, Ancona, Torrette, Italy.

International Ophthalmology

|May 7, 2014

Summary

Psoriasis patients frequently experience ocular involvement, particularly dry eye symptoms. A 12-week immunosuppressive therapy improved ocular surface disease and psoriasis severity, highlighting the need for regular eye exams in psoriatic individuals.

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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Area of Science:

Ophthalmology
Dermatology
Immunology

Background:

Ocular involvement in psoriasis is underrecognized, affecting approximately 10% of patients.
Ophthalmologic manifestations are more prevalent in arthropathic or pustular psoriasis and in males, often coinciding with disease exacerbations.

Purpose of the Study:

To determine the prevalence and characteristics of ocular involvement in psoriasis.
To compare ocular findings between psoriatic patients and healthy controls.
To evaluate the impact of a 12-week systemic immunosuppressive therapy on ocular and dermatological parameters.

Main Methods:

Thirty-two psoriatic patients and 32 healthy controls underwent dermatological (PASI, PGA, DLQI) and ophthalmological evaluations (Schirmer, Jones, BUT, DR-1 camera).
Ocular surface disease index and C-reactive protein (CRP) levels were assessed.
Patients received 12-week systemic immunosuppressive therapy.

Main Results:

Psoriatic patients exhibited significantly lower Schirmer, Jones, and BUT test values and more frequent conjunctival hyperemia compared to controls.
Ocular involvement was more pronounced in sebo-psoriasis, with significant correlations between PASI and Schirmer, Jones, and BUT tests.
After 12 weeks of therapy, significant improvements were observed in PASI, PGA, DLQI, CRP, and BUT values.

Conclusions:

Psoriasis is associated with a high rate of ocular involvement, particularly dry eye disease.
Sebo-psoriasis shows a stronger link with ocular surface parameters.
Systemic immunosuppressive therapy can ameliorate both psoriasis severity and ocular surface disease, underscoring the importance of routine ophthalmological screening for early detection and management.