Related Experiment Video
Updated: Apr 30, 2026
14:19
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
27.4K
First trimester tricuspid regurgitation and fetal abnormalities
Journal of Perinatal Medicine
|May 7, 2014
Summary
Tricuspid regurgitation (TR) is common in fetuses but a poor standalone screening tool for aneuploidy. When TR appears with other markers, it strongly predicts chromosomal abnormalities and cardiac defects.
Area of Science:
- Prenatal diagnosis
- Fetal medicine
- Medical imaging
Background:
- Tricuspid regurgitation (TR) is a frequent finding in fetal ultrasound, present in about 7% of normal fetuses.
- TR can be associated with chromosomal abnormalities (aneuploidy) and congenital heart and extracardiac defects.
Purpose of the Study:
- To characterize fetuses with and without TR between 11 and 13.6 weeks of gestation.
- To compare groups based on chromosomal defects, aneuploidy markers, and fetal cardiac and extracardiac anomalies.
Main Methods:
- Analysis of singleton pregnancies with crown-rump length (CRL) 45-84 mm undergoing ultrasound between 2009-2012.
- Comparison of fetal outcomes, including aneuploidy and malformations, between fetuses with and without TR.
Main Results:
- Out of 1075 fetuses, 96 had TR. Aneuploidy was diagnosed in 6.7% of all fetuses.
- Isolated TR occurred in 5.2% of euploid fetuses. All aneuploid fetuses with TR (40/40) had additional ultrasound markers.
- Extracardiac abnormalities (12.5% vs 1.6%) and cardiac defects (18.8% vs 1.9%) were significantly more frequent in fetuses with TR.
Conclusions:
- TR combined with other ultrasound markers is a strong predictor of fetal aneuploidy.
- TR alone is an ineffective screening tool for chromosomal abnormalities and congenital heart defects.
Related Concept Videos
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
1.2K
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
01:25Cardiovascular System Abnormal Findings II: Auscultation
858
Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
Abnormal Heart Sounds
Gallops:
858
01:20Mitral Regurgitation I: Introduction
1.3K
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
01:23Mitral Regurgitation II: Clinical Features and Diagnostic Tests
943
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
943
01:14Fetal Circulation
5.0K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
5.0K
01:15Aortic Regurgitation I: Introduction
1.6K
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.6K