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O-glycosylation regulates polarized secretion by modulating Tango1 stability

Liping Zhang1, Zulfeqhar Ali Syed2, Iris van Dijk Härd3

  • 1Developmental Glycobiology Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370;

Proceedings of the National Academy of Sciences of the United States of America
|May 7, 2014
PubMed
Summary

O-glycosylation regulates secretion by protecting Tango1 protein from cleavage. Loss of PGANT4 causes secretion defects, which can be rescued by restoring Tango1 or inhibiting furin protease.

Keywords:
Drosophilafamilial tumoral calcinosismucinperitrophic membraneproventriculus

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