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Behavioural outcome in children with congenital adrenal hyperplasia: experience of a single centre

Arini Nuran Idris1, Viji Chandran2, Syed Zulkifli Syed Zakaria2

  • 1Department of Paediatrics, Hospital Putrajaya, Pusat Pentadbiran Putrajaya, Presinct 7, 62250 Putrajaya, Malaysia.

International Journal of Endocrinology
|May 7, 2014
PubMed

Insights

Children with congenital adrenal hyperplasia (CAH) show more behavioral issues, particularly boys with internalizing problems. Family income and glucocorticoid dose may influence these outcomes, highlighting the need for support.

Area of Science:

  • Pediatric Endocrinology
  • Child Psychology
  • Behavioral Science

Background:

  • Congenital adrenal hyperplasia (CAH) is a group of genetic disorders affecting the adrenal glands.
  • Understanding the psychological and behavioral impact of CAH in children is crucial for comprehensive care.

Purpose of the Study:

  • To determine the behavioral outcomes in children with CAH.
  • To identify potential risk factors influencing these behavioral outcomes.

Main Methods:

  • A comparative study involving children with CAH (aged 6-18) and their unaffected siblings.
  • Parent-reported behavioral assessments using the Child Behavior Checklist (CBCL).
  • Analysis of medical records for disease characteristics and treatment information.

Main Results:

  • Children with CAH exhibited higher rates of anxious/depressed, withdrawn/depressed, somatic, social, thought, and attention problems compared to controls.
  • Internalizing behavior problems were more prevalent in CAH boys than in controls.
  • Girls with CAH showed psychosocial adjustment within the normal range, similar to controls.
  • Family income and glucocorticoid dosage were identified as potential factors associated with behavioral outcomes.

Conclusions:

  • Internalizing behavioral problems are common in boys with CAH, indicating potential maladaptive coping with chronic illness.
  • These findings underscore the importance of psychological and social support for children with CAH and their families.
  • Further research into risk factors like family income and treatment variables is warranted.

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