Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signals for glucagon secretion.

S R Bloom

    Ciba Foundation Symposium
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Glucagon regulates blood glucose and acts as a stress hormone. While hormones and metabolites influence its release, the nervous system likely exerts primary control, impacting glucose homeostasis and stress responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effects of various peptides on human isolated gut muscle.

    The Journal of pharmacy and pharmacology·1992
    Same author

    The presence, characterisation and synthesis of neuromedin B in the human pituitary gland.

    Neuroendocrinology·1992
    Same author

    Expression of messenger ribonucleic acids encoding neuropeptide-Y, substance-P, and vasoactive intestinal polypeptide in human pituitary.

    The Journal of clinical endocrinology and metabolism·1992
    Same author

    Effects of peptide YY on the human cardiovascular system: reversal of responses to vasoactive intestinal peptide.

    The American journal of physiology·1992
    Same author

    Characterization of complementary DNA encoding the rat neuromedin U precursor.

    Molecular endocrinology (Baltimore, Md.)·1992
    Same author

    The presence of neuropeptides in GABAergic and cholinergic rat cerebrocortical synaptosome sub-populations.

    Neuropeptides·1992
    Same journal

    Precision agriculture: spatial and temporal variability of environmental quality. General reflections.

    Ciba Foundation symposium·1997
    Same journal

    Uncertainty in hydrogeological modelling.

    Ciba Foundation symposium·1997
    Same journal

    Optimal mapping of site-specific multivariate soil properties.

    Ciba Foundation symposium·1997
    Same journal

    Modelling for precision weed management.

    Ciba Foundation symposium·1997
    Same journal

    GIS support for precision agriculture: problems and possibilities.

    Ciba Foundation symposium·1997
    Same journal

    Spatial sampling.

    Ciba Foundation symposium·1997
    See all related articles

    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Metabolic Regulation

    Background:

    • Glucagon's primary role is controlling hepatic glucose output, maintaining homeostasis, and acting as a stress hormone.
    • Circulating metabolites and hormones influence glucagon release, but the nervous system's role is likely dominant.
    • The parasympathetic nervous system supports homeostasis, while the sympathetic system mediates stress responses.

    Purpose of the Study:

    • To explore the physiological roles of glucagon in glucose homeostasis and stress.
    • To investigate the regulatory mechanisms of glucagon release, emphasizing the nervous system's influence.
    • To examine the relationship between glucagon levels and liver function, particularly in conditions like cirrhosis and hepatic failure.

    Main Methods:

    Related Experiment Videos

  • Review of physiological roles of glucagon.
  • Analysis of factors influencing glucagon release (metabolites, hormones, nervous system).
  • Examination of glucagon levels in pathological conditions (cirrhosis, hepatic failure, glucagonoma, pancreatectomy).

    • Main Results:

    • Glucagon maintains plasma glucose levels and induces hyperglycemia during stress.
    • The nervous system, particularly the sympathetic and parasympathetic branches, appears to exert overriding control on glucagon release.
    • Elevated glucagon in liver failure is likely secondary to metabolic issues, not solely impaired clearance.
    • Glucagon levels are high in glucagonoma syndrome and low after pancreatectomy, with no observed liver abnormalities in the former.

    Conclusions:

    • The nervous system plays a crucial role in regulating glucagon secretion.
    • Liver mass regulation is unlikely to be significantly controlled by glucagon.
    • Understanding glucagon's complex regulation is vital for metabolic and stress response research.