[Human oncogene expression in the normal state and in various blood system diseases]

A study was made of the expression of the cellular oncogens c--myc, c--sis and c--abl in mononuclears from normal donors and patients with different patterns of leukemia and hemopoietic dysplasia using spot hybridization on nitrocellulose filters with virus homologs of the given oncogens. Altogether 43 persons were examined. No specific expression of the oncogens indicated was established whatever the pattern of leukemia. The relationship between the expression of these oncogens and the efficacy of the treatment of acute myeloblastic leukemia was demonstrated. However, in the given investigations, no differences were identified in the expression of oncogens in the leukemic and normal cells stimulated with PHA and phorbolic ether. Enhanced expression of cellular oncogens myc, sis and abl occurred in acute leukemia.