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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Vitamin D and multiple sclerosis.

Asghar Amini Harandi1, Ali Amini Harandi2, Hossein Pakdaman2

  • 1Department of Biochemistry, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Iranian Journal of Neurology
|May 7, 2014
PubMed
Summary
This summary is machine-generated.

Vitamin D modulates immune responses and may influence multiple sclerosis (MS) risk. Vitamin D deficiency or receptor gene variations might increase susceptibility to this disabling neurological disorder.

Keywords:
Multiple SclerosisPolymorphismVitamin DVitamin D Receptor

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Area of Science:

  • Neurology
  • Immunology
  • Endocrinology

Background:

  • Multiple sclerosis (MS) is a chronic, disabling neurological disorder affecting young and middle-aged adults.
  • Its pathogenesis is primarily considered immune-mediated within the central nervous system.
  • Vitamin D influences immune system function and is implicated in autoimmune diseases.

Purpose of the Study:

  • To review the role of vitamin D in the human body.
  • To explore vitamin D's impact on the immune system.
  • To discuss how vitamin D may alter the risk and course of multiple sclerosis.

Main Methods:

  • Literature review of existing studies on vitamin D, immune function, and multiple sclerosis.
  • Analysis of the relationship between vitamin D levels, vitamin D receptor gene polymorphisms, and MS risk.
  • Synthesis of current understanding regarding vitamin D's immunomodulatory effects.

Main Results:

  • Vitamin D acts as an immune system modulator.
  • Deficiency in vitamin D or specific vitamin D receptor gene variations may elevate MS risk.
  • The precise role of vitamin D in MS development and progression requires further investigation.

Conclusions:

  • Vitamin D plays a significant role in immune regulation.
  • Maintaining adequate vitamin D levels may be crucial for reducing MS risk.
  • Further research is warranted to fully elucidate vitamin D's therapeutic potential in multiple sclerosis.