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Trial Watch: Chemotherapy with immunogenic cell death inducers
Erika Vacchelli1, Fernando Aranda1, Alexander Eggermont2
1Gustave Roussy; Villejuif, France ; INSERM, U848; Villejuif, France ; Université Paris-Sud/Paris XI; Paris, France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers; Paris, France.
Oncoimmunology
|May 7, 2014
Summary
Certain anticancer drugs enhance cancer treatment by stimulating the immune system through immunogenic cell death (ICD). This process turns cancer cells into vaccines, promoting an adaptive immune response against tumors.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- The clinical effectiveness of some anticancer drugs is linked to their ability to stimulate anti-tumor immune responses.
- Immunogenic cell death (ICD) is a key mechanism where chemotherapy prompts the immune system to target cancer cells.
- Cancer cells undergoing ICD can act as in-situ vaccines, eliciting adaptive immunity.
Approach:
- This review summarizes recent findings on ICD-inducing anticancer drugs.
- Focuses on clinical trials and high-impact studies published within the last 13 months.
- Examines cyclophosphamide, doxorubicin, epirubicin, oxaliplatin, and mitoxantrone for their immunogenic properties.
Key Points:
- Several conventional and targeted anticancer agents can induce ICD.
- ICD converts dying cancer cells into immunogenic material, stimulating T-cell responses.
- Ongoing clinical trials are investigating these ICD-inducing drugs, including off-label uses.
Conclusions:
- Anticancer drugs that induce ICD hold significant therapeutic potential by harnessing the immune system.
- Further research and clinical trials are crucial to optimize the use of these immunogenic agents in cancer therapy.
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