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Updated: Aug 20, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Ugi-based approaches to quinoxaline libraries
Jhonny Azuaje1, Abdelaziz El Maatougui, Xerardo García-Mera
1Center for Research in Biological Chemistry and Molecular Materials (CIQUS), ‡Institute of Industrial Pharmacy, and §Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Santiago de Compostela 15782, Spain.
Abstract:
An expedient and concise Ugi-based unified approach for the rapid assembly of quinoxaline frameworks has been developed. This convergent and versatile method uses readily available commercial reagents, does not require advanced intermediates, and exhibits excellent bond-forming efficiency, thus exemplifying the operationally simple synthesis of quinoxaline libraries.

