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Updated: Apr 30, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
[Acute coronary syndrome after chemotherapy]
Mijntje B Vastbinder1, Henk Drost, Erik W Muller
1Slingeland Ziekenhuis, Doetinchem.
Systemic cancer treatments can trigger acute coronary syndrome (ACS), even in patients without heart disease risk factors. Prompt recognition and management of ACS are crucial before deciding on continuing chemotherapy.
Area of Science:
- Oncology
- Cardiology
- Pharmacology
Background:
- Systemic therapy for malignancy is associated with potential cardiovascular complications.
- Acute coronary syndrome (ACS) can occur irrespective of pre-existing cardiovascular risk factors.
Observation:
- Three patients with minimal cardiovascular risk factors developed ACS within a week of initiating systemic cancer treatment.
- The cancers treated were colorectal cancer, non-Hodgkin's lymphoma, and breast cancer.
- Chemotherapy, including capecitabine, was implicated in the onset of ACS.
Findings:
- Systemic anti-cancer therapy was continued in all patients after individualized treatment adjustments.
- Early recognition of the link between chemotherapy and ACS is vital.
- Withholding systemic anti-cancer treatment until ACS is resolved is recommended.
Implications:
- Clinicians must consider the potential for chemotherapy-induced ACS.
- Treatment decisions require careful consideration of cancer intent, alternative regimens, ACS outcome, and patient preference.
- Individualized management strategies are essential for patients experiencing ACS during cancer therapy.
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