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Updated: Apr 30, 2026

Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain
Published on: December 20, 2012
Oligodendrocyte progenitors: adult stem cells of the central nervous system?
A H Crawford1, J H Stockley1, R B Tripathi2
1Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge, CB2 0SP; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Abstract:
Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name 'oligodendrocyte progenitor' suggests restriction to the oligodendrocyte cell lineage. However, with growing evidence of the lineage plasticity of OPs both in vitro and in vivo, we discuss whether they have potential beyond that expected of dedicated progenitor cells, and hence may justify categorization as adult stem cells.
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