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Related Concept Videos

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

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Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
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Roles of Electrolytes: Calcium and Phosphate01:27

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Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Related Experiment Video

Updated: Apr 30, 2026

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
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Circulating FGF23 levels in response to acute changes in plasma Ca(2+).

Eva Gravesen1, Maria L Mace, Jacob Hofman-Bang

  • 1Nephrological Department P, Rigshospitalet, University of Copenhagen, 2100, Copenhagen, Denmark.

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Calcium (Ca) does not acutely regulate fibroblast growth factor 23 (FGF23) secretion. Studies show plasma FGF23 levels remained stable during induced hypercalcemia and hypocalcemia in rats.

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Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
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Area of Science:

  • Endocrinology
  • Mineral Metabolism
  • Renal Physiology

Background:

  • Fibroblast growth factor 23 (FGF23) is crucial for phosphate and vitamin D regulation.
  • Calcium (Ca) and phosphate homeostasis are interconnected, suggesting a potential role for Ca in FGF23 regulation.
  • Previous studies indicated dietary Ca affects FGF23, but acute plasma Ca effects remain unclear.

Purpose of the Study:

  • To investigate the impact of acute hypercalcemia and hypocalcemia on FGF23 levels in rats.
  • To determine if a direct relationship exists between plasma Ca and FGF23 secretion, similar to Ca and parathyroid hormone (PTH).

Main Methods:

  • Acute hypercalcemia induced via intravenous Ca infusion.
  • Acute hypocalcemia induced via ethylene glycol tetraacetic acid (EGTA) infusion.
  • Measurements included intact plasma FGF23, intact plasma PTH, plasma Ca(2+), and phosphate in normal and parathyroidectomized rats.

Main Results:

  • Induced hypercalcemia and hypocalcemia elicited appropriate PTH secretory responses.
  • Plasma FGF23 levels remained consistently stable across all tested plasma Ca(2+) concentrations.
  • Acute parathyroidectomy did not influence FGF23 secretion.

Conclusions:

  • Acute changes in plasma Ca levels do not regulate FGF23 secretion.
  • Calcium is not an acute regulator of fibroblast growth factor 23 secretion.