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Updated: Apr 30, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
[Tumor microenvironment: regulatory cells and immunosuppressive cytokines]
Mélanie Bruchard1, François Ghiringhelli2
1Inserm, faculté de médecine et de pharmacie de Dijon, 7, boulevard Jeanne d'Arc, Dijon, France.
Abstract:
Immunosuppression is a mechanism developed by cancer cells to help them escape the immune system. Immunosuppression involves expansion of various cell types and production of a variety of cytokines. In this review, we explore the duality of three cancer induced cell populations, regulatory T lymphocytes, Th17 lymphocytes and MDSC, and also the pleiotropic effects of several cytokines induced during cancer development.
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