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Accessing new chemical entities through microfluidic systems.

Tiago Rodrigues1, Petra Schneider, Gisbert Schneider

  • 1Eidgenössische Technische Hochschule (ETH) Zürich, Departement für Chemie und Angewandte Biowissenschaften, Vladimir-Prelog-Weg 4, 8093 Zürich (Switzerland).

Angewandte Chemie (International Ed. in English)
|May 8, 2014
PubMed
Summary

Microfluidic flow systems are revolutionizing chemical research, enabling miniaturized bioanalytical methods and the synthesis of bioactive small molecules for drug discovery. This technology is reshaping chemical biology and molecular medicine.

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Area of Science:

  • Chemical Engineering
  • Organic Chemistry
  • Medicinal Chemistry

Background:

  • Flow systems are widely used in chemical research and development.
  • Microfluidic technologies are increasingly employed for discovering new chemical entities.
  • These advancements are transforming chemical biology and molecular medicine.

Purpose of the Study:

  • To review the state-of-the-art in microfluidic reactor applications.
  • To highlight recent advances in synthesizing bioactive small molecules using micro- and mesoscale coil reactors.
  • To forecast the future potential of microfluidic technology in chemical research.

Main Methods:

  • Review of current literature and recent advances in microfluidic reactor technology.
  • Analysis of applications in synthetic (bio)organic chemistry and (bio)analytical methods.
Keywords:
chemical biologydrug discoverylab-on-a-chiporganic synthesis

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  • Focus on microchip reactors and micro-/mesoscale coil reactors.

    • Main Results:

    • Microfluidic systems facilitate the miniaturization of analytical and synthetic processes.
    • Micro- and mesoscale coil reactors are effective for synthesizing bioactive small molecules.
    • The technology shows significant promise for accelerating drug discovery and development.

    Conclusions:

    • Microfluidic flow systems represent a significant technological advancement in chemical research.
    • Their application in synthesizing bioactive small molecules is rapidly expanding.
    • Continued development is expected to drive innovation in chemical biology and molecular medicine.