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Understanding the colloidal stability of the mesoporous MIL-100(Fe) nanoparticles in physiological media
Elena Bellido1, Mazheva Guillevic, Tania Hidalgo
1Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines , 45 avenue des Etats-Unis, 78035 Versailles cedex, France.
Abstract:
The colloidal and chemical stability of nanoparticles of the nontoxic and biodegradable iron(III) trimesate MIL-100(Fe) nanocarrier have been evaluated in the presence of a series of simulated physiological fluids for intravenous and oral administration. MIL-100(Fe) nanoparticles exhibit an appropriate colloidal stability and biodegradability, mainly dependent on both the nature of their physicochemical surface and the media composition, being a priori compatible with their biomedical use.
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