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Enzymes in cancer.

¹Department of Clinical Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York.

Clinics in Laboratory Medicine

|December 1, 1989

Summary

Serum enzyme measurements are not effective for initial cancer screening or diagnosis. However, they are valuable for confirming diagnoses, staging disease, predicting prognosis, and monitoring patient progress.

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Area of Science:

Biochemistry
Oncology
Medical Diagnostics

Background:

Serum enzyme measurements are frequently evaluated in clinical practice.
Their utility as standalone diagnostic tools for cancer is debated.

Purpose of the Study:

To clarify the role of serum enzyme measurements in cancer management.
To differentiate between screening, diagnosis, staging, and prognosis.

Main Methods:

Review of existing literature on serum enzyme markers in oncology.
Analysis of the clinical application of tumor markers.

Main Results:

Serum enzymes lack utility for cancer screening and primary diagnosis.
These markers are crucial for diagnostic confirmation and disease staging.
Enzymatic markers aid in prognosis prediction and disease course monitoring.

Conclusions:

Serum enzyme measurements are not recommended for cancer screening.
Their established roles are in confirming diagnoses, staging, and monitoring cancer progression.

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