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Interaction of citrate with Fe(III)-bleomycin
1Institute of Medical Biochemistry, University of Oslo, Norway.
The International Journal of Biochemistry
|January 1, 1989
Abstract:
1. Citrate binds to Fe(III)-bleomycin, removing the ferric ion from the iron-drug complex; a reaction that may be of physiological significance. 2. Low concentrations of citrate markedly enhance the rate of iron transfer from Fe(III)-bleomycin to apotransferrin; an iron binding plasma protein.