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Protection from chlordecone (Kepone)-potentiated CCl4 hepatotoxicity in rats by fructose 1,6-diphosphate
1Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216-4505.
Abstract:
1. The extent of liver injury assessed as elevation of plasma transaminases was decreased 40-50% by administration of fructose 1,6-diphosphate to rats receiving the highly hepatotoxic combination of chlordecone and CCl4. 2. This protection was accompanied by significantly higher sustenance of ATP levels in the liver. 3. Polyamine synthesis as well as interconversion were stimulated in favor of maintaining higher levels of polyamines. 4. These events are consistent with the concept that suppressed hepatocellular regeneration which leads to progression of otherwise limited injury observed in chlordecone potentiation of CCl4 hepatotoxicity is due to lack of cellular energy.