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Related Concept Videos

Classification of Leukocytes01:30

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Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
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Golgi Matrix Proteins01:12

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Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
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Protein Modifications in the RER01:26

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Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
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Overview of Secretory Vesicles01:33

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
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Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

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Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
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Conjugated Proteins

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
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Related Experiment Video

Updated: Apr 30, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

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Eosinophil granule proteins: form and function.

K Ravi Acharya1, Steven J Ackerman2

  • 1From the Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom and K.R.Acharya@bath.ac.uk.

The Journal of Biological Chemistry
|May 8, 2014
PubMed
Summary
This summary is machine-generated.

Eosinophils and their granule proteins are crucial in asthma and allergic diseases. Their role in airway inflammation, damage, and remodeling highlights their significance in disease pathogenesis.

Keywords:
AsthmaCrystal StructureEnzyme StructureEosinophilEosinophil Granule ProteinsInflammation

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Area of Science:

  • Immunology
  • Cell Biology
  • Pathophysiology

Background:

  • Eosinophils play a key role in asthma, allergic, and parasitic diseases.
  • They also modulate innate and adaptive immunity, tissue repair, and homeostasis.
  • Eosinophils recruit Th2-polarized T-cells, linking innate and adaptive immunity in allergic airway inflammation.

Purpose of the Study:

  • To review molecular aspects of eosinophil-derived granule proteins.
  • To advance understanding of their structure-function relationships.
  • To elucidate their roles in eosinophil biology and immunobiology in health and disease.

Main Methods:

  • Review of experimental and clinical data.
  • Analysis of studies using eosinophil-deficient mouse models.
  • Examination of eosinophil-derived granule protein double knock-out mice (MBP-1/EP).

Main Results:

  • Eosinophils are essential for major asthma hallmarks: airway epithelial damage, hyperreactivity, and remodeling.
  • Eosinophil granule proteins contribute to airway inflammation, tissue damage, and remodeling in asthma.
  • Studies confirm eosinophils' requirement for asthma pathophysiology.

Conclusions:

  • Eosinophil granule proteins are key mediators in asthma pathogenesis.
  • Understanding their structure-function relationship is vital for comprehending eosinophil roles in health and disease.
  • Eosinophils are critical players in allergic airway inflammation and tissue remodeling.