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A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Murat Dereli, Bartlomiej E Krazinski, Suleyman Ayvaz1

  • 1Department of Pediatric Surgery, Trakya University Faculty of Medicine, Edirne, Turkey. suleyayvaz@yahoo.com.

Folia Histochemica Et Cytobiologica
|May 8, 2014
PubMed

Insights

Olmesartan effectively prevents esophageal strictures after corrosive burns by reducing tissue damage and apoptosis. This study demonstrates olmesartan

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Regenerative Medicine

Background:

  • Corrosive ingestion causes esophageal damage and stricture formation.
  • Olmesartan exhibits anti-inflammatory, antifibrotic, and antiapoptotic properties in injured tissues.

Purpose of the Study:

  • To investigate the efficacy of olmesartan in preventing esophageal stricture formation in a corrosive esophageal burn model.

Main Methods:

  • Fifty-one rats were divided into six groups, including control and olmesartan-treated burn groups.
  • Esophageal morphology, apoptosis (TUNEL), serum nucleosomes, and p53 protein levels were assessed.
  • Olmesartan (5 mg/kg) was administered daily for 21 days post-injury.

Main Results:

  • Olmesartan significantly reduced muscularis mucosa damage, submucosal collagen deposition, and tunica muscularis injury in burned esophagi.
  • A significant decrease in apoptotic cells was observed in the olmesartan-treated burn group.
  • Serum nucleosome and p53 levels, as well as tissue p53 protein, showed no significant differences between groups.

Conclusions:

  • Olmesartan administration effectively prevents esophageal strictures resulting from corrosive esophageal burns.
  • The drug's protective effects are linked to reduced tissue damage and apoptosis.

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