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Updated: Apr 30, 2026
Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Size controlled hydroxyapatite and calcium carbonate particles: synthesis and their application as templates for SERS
B V Parakhonskiy1, Yu I Svenskaya2, A М Yashchenok3
1Department of Physics, University of Trento, 38122 Trento, Italy; A.V. Shubnikov Institute of Crystallography RAS, 119333 Moscow, Russia.
Abstract:
An elegant route for hydroxyapatite (HA) particle synthesis via ionic exchange reaction is reported. Calcium carbonate particles (CaCO3) were recrystallized into HA beads in water solution with phosphate ions. The size of initial CaCO3 particles was controlled upon the synthesis by varying the amount of ethylene glycol (EG) in aqueous solution. The average size of HA beads ranged from 0.6±0.1 to 4.3±1.1μm. Silver nanoparticles were deposited on the surface of HA and CaCO3 particles via silver mirror reaction. Surface enhanced Raman scattering of silver functionalized beads was demonstrated by detecting Rhodamine B. CaCO3 and HA particles have a great potential for design of carrier which can provide diagnostic and therapeutic functions.
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