Intravitreal dexamethasone implant for acute exudative polymorphous vitelliform maculopathy

Area of Science:

• Ophthalmology
• Retinal Diseases
• Macular Degeneration

Background:

• Acute exudative polymorphous vitelliform maculopathy (AEPVM) is a rare condition causing macular detachment and subretinal deposits.
• Systemic corticosteroids have yielded mixed results for AEPVM, leaving their efficacy undetermined.

Observation:

• This is the first reported case of AEPVM treated with an intravitreal dexamethasone implant (Ozurdex) in one eye.
• A 28-year-old male with AEPVM received an intravitreal dexamethasone implant in his left eye.

Findings:

• The intravitreal dexamethasone implant did not significantly change the clinical progression of AEPVM compared to the untreated eye.
• No complications related to the intravitreal implant were observed during the follow-up period.

Implications:

• The lack of response suggests intravitreal corticosteroids may not be an effective treatment for AEPVM.
• Further research is needed to determine optimal therapeutic strategies for this rare retinal disorder.